The kidneys are very important body organs. Normal kidneys filter and remove waste materials that result from normal body functioning from the blood stream. They also regulate the amount of fluid retained by the body as well as play a major role in maintaining the overall strength of the blood supply. Anemia is a common problem in pets with chronic kidney disease.

Kidney disease may have many causes: inherited defects, infections, poisons and toxic substances, and nutritional factors. Old age is also a common factor in the condition termed “chronic renal failure” and is the primary cause of death in many older pets. Often the exact cause of kidney failure cannot be determined, but with careful examination and testing, the severity of the disease can be evaluated so that the best method of management for the condition can be recommended. Some of these tests include:

SIGNS OF CHRONIC KIDNEY DISEASE ARE A RESULT OF BODY WASTE MATERIALS BUILDING UP IN THE BLOODSTREAM BECAUSE THE KIDNEYS ARE NOT FUNCTIONING PROPERLY.

TREATMENT OF CHRONIC KIDNEY DISEASE. In the early stages of chronic kidney failure, successful management is possible by feeding special prescription diets. These prescription foods will help control salt loss and reduce the amount of toxic waste products that are found in regular foods, which heavily burden weakened kidneys. Several diets are available and the appropriate one will be recommended for your particular pet after evaluation to determine the severity of the problem. It is very important to follow our diet recommendations closely. Nothing else should be fed (including treats!) without our recommendation. This means no meat, eggs, cheese, bones, or rawhide chew strips. Fresh clean water should always be available to the pet. Limiting water availability to your pet can be fatal. Frequent monitoring of the various tests related to kidney function is a must to provide your pet the longest and best quality of life possible.

CHRONIC KIDNEY DISEASE: Helping Your Patient Live With It

The main function of the kidney is to remove metabolic poisons and waste products from the body’s blood supply. The kidneys act as in-line filters for the blood stream.

All of the body’s blood circulates through the kidneys eventually. There it is cleansed of all chemicals not needed by the body. The kidneys filter the blood in two steps. In the first step, nearly all of the dissolved chemicals are removed from the blood. In the second step, some of the desirable items such as blood sugar, most of the water, and certain other essential substances are returned to the blood stream. All of the chemicals that were filtered out of the blood in the first step and not returned to the blood in the second step are excreted as urine.

That’s the way it is supposed to work. But kidney disease changes things. Kidney disease is an insidiously progressive disease that destroys the kidney. Causes of kidney disease include birth defects, bacterial or viral infections, injury, certain medications, poisons, kidney stones, bladder stones, cancer and many other things. Frequently, the cause cannot be determined. If the kidneys are damaged severely, they will not be able to perform properly, so waste materials accumulate in the blood, poisoning the body.

Signs of kidney disease become apparent once damage reaches the point at which the kidneys cannot rid the body of the metabolic waste products that accumulate continuously, or when the delicate fluid/electrolyte balance of the body cannot be maintained. This point varies from pet to pet, but in general, 2/3 of the functional kidney mass must be lost before symptoms of kidney disease become apparent. Once a kidney is damaged, regeneration does not occur.

It is important to remember that the body can continue to function fairly normal as long as there remains at least 10% functional kidney tissue. In our experience, many pets are able to live out fairly normal lives with kidney disease as long as it is detected early, and proper treatment and diet changes are started promptly.

Signs of Kidney Disease

Signs of kidney disease can appear suddenly or develop slowly over time. Other diseases can also produce the same constellation of symptoms. Initial signs of kidney disease include: malaise or lethargy, loss of appetite, poor or unkempt haircoat, increased water consumption (often overlooked in cats), and increased urination

Later signs include vomiting, diarrhea, depression, and dehydration. This latter development is often surprising to pet owners. It results from an inadequate amount of water in the body, from water loss due to vomiting, from inability to drink and/or from excessive urine output.

Once severe kidney damage has occurred, excessive urine is allowed to pass through the kidneys. This is actually a defensive mechanism employed by the kidneys. Unfortunately, there is a tendency over time for this to result in dehydration. The dehydration, in turn, causes the pet to drink more and more, leading to a continually increasing volume of urine. The cycle gets worse and worse.

Vomiting, diarrhea, and difficult breathing appear as the disease progresses with a buildup of waste products in the blood stream. Anemia may occur in severe cases because hormones from the kidneys are involved in the production of red blood cells.

Treatment: Treatment of kidney diseases is general focused on the following general concepts:

* Maintenance of proper hydration and water intake.

* Dietary optimization.

* Stress avoidance.

* Elimination or minimization of other treatable concurrent problems that may be interfering with kidney function. This includes things such as:

1. Infection

2. Partial or complete urinary output obstruction

3. Heart disease

4. Electrolyte imbalances

GENERAL MANAGEMENT STRATEGIES FOR PETS WITH KIDNEY DISEASE

1. Maintain access to fresh, clean, water at all times. Change the water daily.

2. Protect your pet from environmental and psychological stresses. These would include such things as extreme exertion, excitement, excessively hot or cold temperatures, new household pets, kenneling, long trips, excessive exercise, etc.

3. Diet optimization is one of the cornerstones of kidney disease management.

Feed only Prescription Diet k/d® or Prescription Diet u/d® as directed. These diets are specially formulated to reduce the demands on the kidney. The highest quality protein available must be utilized to decrease the continuing damage occurring within the kidneys.

If your pet is a nibbler (most cats are), leave food available at all times. Otherwise, feed 3-4 small meals daily, rather than one large meal. Allow your pet to eat all that it wants, unless free-choice feeding causes obesity. If weight loss occurs in spite of good appetite, increase the amounts of dietary fats for cats or increase the amounts of dietary carbohydrates for dogs. Maintain your pet’s body weight at an optimal level. Your pet should be trim and have a marked waistline.

Warning: Many pets initially refuse the new food. BE PERSISTENT. Match wits with them. Dietary optimization is crucial for long term maintenance. Getting your pet on the right food could literally add years to his/her life.

If your pet absolutely refuses to eat any k/dÒ or u/dÒ, then try one of the homemade diets shown below. Be aware, however, that these homemade diets are not nearly as beneficial to the pet as the k/dÒ or u/dÒ,.

All of these special diets - k/dÒ or u/dÒ,, and the homemade diets - should be supplemented with additional amounts of the water-soluble vitamins (B & C) and zinc.

4. Additional medications may be required depending on the severity and type of kidney disease present.

Some patients require an oral phosphorous binder to help reduce blood phosphorous levels.

Some patients require medication to suppress vomiting.

Some patients require medications to help acidify the blood.

Some patients require genetically engineered medications to reverse their anemia.

Other require a special type of vitamin D₃ to help normalize calcium balance.

5. Repeat kidney tests and urinalysis every 30-60 days, until your pet’s condition has been stabilized, and then every 4 months from then on.

Cook the beef in a skillet, stirring until lightly browned. Stir in the remaining ingredients and mix well. The resulting mixture is somewhat dry and its palatability can be improved by adding a little water (not milk). Keep covered in refrigerator. Yields about 1 ¼ lb.

Initially, feed at a rate of ¼ lb of food per 5 lb of body weight. Adjust up or down as necessary to maintain normal body weight.

Dice and braise the meat, retaining all the fat. Combine all ingredients and mix well. The resulting mixture is somewhat dry and its palatability can be improved by adding a little water (not milk). Keep covered in refrigerator. Yields about 1 ¼ lb.

Initially, feed at a rate of ¼ lb of food per 5 lb of body weight. Adjust up or down as necessary to maintain normal body weight.

2. Avoid physical or psychological stress if possible. (such as kenneling, long trips, excessive exercise, etc.)

3. Regulate your pet’s diet. Feed only a prescription kidney diet (Prescription Diet k/dÒ or u/dÒ,) or a special homemade diet:

B. Low amount, high-quality protein (cooked egg, chicken, fish, lean muscle meat)

D. Restrict salt intake. Do not use ingredients with a lot of preservatives, as they are usually sodium salts which can lead to high blood pressure in pets with kidney disease.

E. To increase palatability, warm the food or mix in well a little chicken fat or unsalted butter.

4. If your pet is a nibbler, leave food available at all times. Otherwise, feed 3-4 small meals daily rather than

one large meal. Allow your pet to eat all that it wants, unless free-feeding causes obesity. If weight loss

occurs in spite of good appetite, increase fats (cats) or carbohydrates (dogs). There are also drugs which can be used to increase appetite.

5. Maintain your pet’s body weight at an optimal level. Your pet should be trim and have a marked waistline.

6. Supplement with water-soluble vitamins (B & C) and zinc. Give zinc at 1/2 milligram/pound body weight per day.

7. Repeat kidney tests and urinalysis every 30-60 days until your pet’s condition has been stabilized and then every 4 months from then on.

8. Give your pet 300 milligrams of calcium carbonate/11 pounds of body weight every 12 hours or with each meal to treat an increased acid content of the blood. This dose equals about one level teaspoon/60 #.

9. Give your pet 60 milligrams of aluminum hydroxide (1/5 of an Amphogel 300 tablet) per 11 pounds of body weight every 12 hours or with meals to lower phosphorous absorption from food.